Hey John, these guys pretty much got you covered, but as I use (and love) Wicked paints and an Iwata HP-CS (has a .35 nozzle, and no mac valve but I believe(?) they are fairly similar guns), thought I'd weigh in.
First of all, I think everyone goes through this frustration, so rest assured - you are not alone LOL. The detail paints in particular, can have teeny, teeny gloopy bits sometimes (not always), so I would recommend filtering the paint - some pantyhose stretched over the neck works fine. Also try and get the W500 reducer (W100 is fine too, but the W500 is even better), the reducers help with tip dry, and depending on the reduction used, can make it negligable, and also helps give a nice smooth flow. (note - also helps to dry quicker, so not the best for using erasing techniques).
As has been said, there is no magic formula, too many variables involved, and even people with the same set up, may reduce differently, depending on what, and how they like to paint, weather conditions etc. But I use a ratio of 3 drops reducer to one drop paint @ 20 psi (4 drops for black, and some other colours - you will soon get to know the paints). This is my standard base mixture, and I adjust accordingly from there, adding another drop or two if needed, or tweaking the psi a bit (no probs for the mac valve
) Your nozzle is slightly finer, so you may need a bit more reduction, or higher pressure to find your own base. (Or you may end up with something totally different Lol), but the rule of thumb is more reduction = less pressure. Some people like to go as low as 5psi and use 20 or so drops reducer, basically just see what works for you, then play with it a bit to see if it gets better or worse.
It sounds like a complete pain in the you know where, but it really does become second nature pretty quickly. I also give the gun a good blast now and then, to keep the nozzle clear, and flush through with water, or reducer, between colour changes. Also some of the problems sound similar to if you have a blocked or dirty nozzle (filtering may help with that), even if it looks clean as a whistle, stuff hides in there Lol, and it's always worth giving it a clean, just to rule it out of the equation.
You must be feeling frustrated right now, but you'll get there, good luck!